Disk or Network Error

I am trying to connect to the Access Database on the server and I get the following error:

Microsoft OLE DB Provider for ODBC Drivers (0x80004005)
[Microsoft][ODBC Microsoft Access Driver] Disk or network error.

I was searching on the net and came through the article published by Microsoft
http://support.microsoft.com/defaul...&NoWebContent=1

According to this, I had changed the environment variables , both TMP & TEMP pointing to the folder that has the access DB. I was through with the error. But what I saw was, I couldn't open any of the desktop items from anywhere(not only from desktop) on the server. Previously, the TMP and TEMP were set to the path C:\Documents&Settings\......\LocalSettings. So , I changed the settings back and this time without re-starting the server, I could open the desktop items as before. When I re-started the server the next day, I couldn't connect to the Access(.mdb) file. So, I changed one of the variables TMP to the path C:\accessDBfolder\accessfilename. It isn't working. Do I have to change both the variables. Is there any other alternative solution to this. What if I have more Access DB files, should I keep changing the variables all the time. With what name should I create a new variable. Could someone please help me!